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Last updated: 2016/12/4
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ACVRL1 polyclonal antibody

  • Catalog # : PAB3475
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of ACVRL1.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ACVRL1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • Flow Cytometry (1:10-50)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
    Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of ACVRL1 polyclonal antibody (Cat # PAB3475) in mouse heart tissue lysate.
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western blot analysis of ACVRL1 polyclonal antibody (Cat # PAB3475) in human chondrocytes (C-28/I2 cells), transfected with empty vector (lane 1, 3) or ACVRL1 (lane 2, 4). RIPA lysis buffer, 20 ug/lane of protein, primary antibody dilution 1 : 1000, blocking solution is 5% milk in TBST (lane 1 and 2), 5% BSA in TBST (lane 3 and 4).
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western blot analysis of ACVRL1 (arrow) using rabbit ACVRL1 polyclonal antibody (Cat # PAB3475). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVRL1 gene (Lane 2) (Origene Technologies).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ACVRL1 polyclonal antibody (Cat # PAB3475) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of HepG2 cells using ACVRL1 polyclonal antibody (Cat # PAB3475)(bottom histogram) compared to a negative control cell (top histogram).
    FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 94
  • Gene Name:
  • ACVRL1
  • Gene Alias:
  • ACVRLK1,ALK-1,ALK1,HHT,HHT2,ORW2,SKR3,TSR-I
  • Gene Description:
  • activin A receptor type II-like 1
  • Gene Summary:
  • This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq
  • Other Designations:
  • TGF-B superfamily receptor type I,activin A receptor, type II-like kinase 1,serine/threonine-protein kinase receptor R3
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