ACVR1B polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The ACVR1B polyclonal antibody (Cat # PAB3465) is used in Western blot to detect ACVR1B in mouse kidney tissue lysate.
Flow Cytometry
Flow cytometric analysis of 293 cells using ACVR1B polyclonal antibody (Cat # PAB3465)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ACVR1B.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ACVR1B.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Flow Cytometry (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The ACVR1B polyclonal antibody (Cat # PAB3465) is used in Western blot to detect ACVR1B in mouse kidney tissue lysate.Flow Cytometry
Flow cytometric analysis of 293 cells using ACVR1B polyclonal antibody (Cat # PAB3465)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. -
Gene Info — ACVR1B
Entrez GeneID
91Protein Accession#
P36896Gene Name
ACVR1B
Gene Alias
ACTRIB, ACVRLK4, ALK4, SKR2
Gene Description
activin A receptor, type IB
Omim ID
601300Gene Ontology
HyperlinkGene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
Other Designations
activin A receptor, type II-like kinase 4|activin A type IB receptor|activin receptor-like kinase 4|serine(threonine) protein kinase receptor R2
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Interactome
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Pathway
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Disease
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Publication Reference
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Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.
Mukasa C, Nomura M, Tanaka T, Tanaka K, Nishi Y, Okabe T, Goto K, Yanase T, Nawata H.
Endocrinology 2003 Apr; 144(4):1603.
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Identification of a functional binding site for activin on the type I receptor ALK4.
Harrison CA, Gray PC, Koerber SC, Fischer W, Vale W.
The Journal of Biological Chemistry 2003 Jun; 278(23):21129.
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Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells.
Danila DC, Zhang X, Zhou Y, Haidar JN, Klibanski A.
The Journal of Clinical Endocrinology and Metabolism 2002 Oct; 87(10):4741.
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Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.
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