FGR polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The FGR polyclonal antibody (Cat # PAB3425) is used in Western blot to detect FGR in Ramos cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with FGR polyclonal antibody (Cat # PAB3425) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FGR.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human FGR.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunofluorescence (1:10-50)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The FGR polyclonal antibody (Cat # PAB3425) is used in Western blot to detect FGR in Ramos cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with FGR polyclonal antibody (Cat # PAB3425) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Immunofluorescence
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Gene Info — FGR
Entrez GeneID
2268Protein Accession#
P09769Gene Name
FGR
Gene Alias
FLJ43153, MGC75096, SRC2, c-fgr, c-src2, p55c-fgr, p58c-fgr
Gene Description
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Omim ID
164940Gene Ontology
HyperlinkGene Summary
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000003601|OTTHUMP00000003602|OTTHUMP00000003603|c-fgr protooncogene|c-src-2 proto-oncogene|p55-c-fgr protein|proto-oncogene tyrosine-protein kinase FGR
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Interactome
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Publication Reference
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Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions.
Carriero MV, Franco P, Gargiulo L, Vocca I, Cito L, Fontana L, Iaccarino C, Del Pozzo G, Guardiola J, Stoppelli MP.
Biological Chemistry 2002 Jan; 383(1):107.
Application：IP, KA, Human, U937 cells.
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Primary structure of the human fgr proto-oncogene product p55c-fgr.
Katamine S, Notario V, Rao CD, Miki T, Cheah MS, Tronick SR, Robbins KC.
Molecular and Cellular Biology 1988 Jan; 8(1):259.
Application：IP, Monkey, COS-1 cells.
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Structure, expression, and chromosomal location of the human c-fgr gene.
Nishizawa M, Semba K, Yoshida MC, Yamamoto T, Sasaki M, Toyoshima K.
Molecular and Cellular Biology 1986 Feb; 6(2):511.
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Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions.
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