Products

Western Blot (Cell lysate)

Western blot analysis of RYK polyclonal antibody (Cat # PAB3389) in Jurkat cell lysate. RYK (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with RYK polyclonal antibody (Cat # PAB3389) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Entrez GeneID

6259

Protein Accession#

P34925

Gene Name

RYK

Gene Alias

D3S3195, JTK5, JTK5A, RYK1

Gene Description

RYK receptor-like tyrosine kinase

Omim ID

600524

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms. [provided by RefSeq

Other Designations

JTK5A protein tyrosine kinase|hydroxyaryl-protein kinase