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Last updated: 2017/9/24
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DDR1 polyclonal antibody

  • Catalog # : PAB3365
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of DDR1.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to 24-54 amino acids at N-terminus of human DDR1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • Flow Cytometry (1:10-50)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-50)
    Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of DDR1 polyclonal antibody (Cat # PAB3365) in placenta lysate. MCK10 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Formalin-fixed and paraffin-embedded human cancer tissue reacted with DDR1 polyclonal antibody (Cat # PAB3365) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
  • Flow Cytometry
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 780
  • Protein Accession#:
  • NP_054699;Q08345
  • Gene Name:
  • DDR1
  • Gene Alias:
  • CAK,CD167,DDR,EDDR1,MCK10,NEP,NTRK4,PTK3,PTK3A,RTK6,TRKE
  • Gene Description:
  • discoidin domain receptor tyrosine kinase 1
  • Gene Summary:
  • Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000029343,OTTHUMP00000029344,OTTHUMP00000029345,OTTHUMP00000029346,OTTHUMP00000029347,PTK3A protein tyrosine kinase 3A,cell adhesion kinase,discoidin domain receptor DDR1d,discoidin domain receptor family, member 1,discoidin receptor tyrosine kin
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