TLK2 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TLK2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human TLK2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TLK2 polyclonal antibody (Cat # PAB3319) in A-375 cell lysate. TLK2 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. -
Gene Info — TLK2
Entrez GeneID
11011Protein Accession#
Q9UKI7Gene Name
TLK2
Gene Alias
MGC44450, PKU-ALPHA
Gene Description
tousled-like kinase 2
Omim ID
608439Gene Ontology
HyperlinkGene Summary
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM
Other Designations
serine/threonine kinase
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Interactome
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Disease
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Publication Reference
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Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
Groth A, Lukas J, Nigg EA, Sillje HH, Wernstedt C, Bartek J, Hansen K.
The EMBO Journal 2003 Apr; 22(7):1676.
Application:IP, WB-Tr, Human, AT fibroblasts, HCT-15, HeLa, HT-29, U-2 OS cells.
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA,
PNAS 2002 Dec; 99(26):16899.
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Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.
Sillje HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA.
The EMBO Journal 1999 Oct; 18(20):5691.
Application:IF, IP, KA, WB-Ce, WB-Re, Human, HeLa cells, Recombinant protein, U2-OS cells.
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Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
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