PAPSS2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The PAPSS2 polyclonal antibody (Cat # PAB3306) is used in Western blot to detect PAPSS2 in Jurkat cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with PAPSS2 polyclonal antibody (Cat # PAB3306) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PAPSS2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PAPSS2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The PAPSS2 polyclonal antibody (Cat # PAB3306) is used in Western blot to detect PAPSS2 in Jurkat cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with PAPSS2 polyclonal antibody (Cat # PAB3306) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — PAPSS2
Entrez GeneID
9060Protein Accession#
NP_001015880Gene Name
PAPSS2
Gene Alias
ATPSK2, SK2
Gene Description
3'-phosphoadenosine 5'-phosphosulfate synthase 2
Omim ID
603005Gene Ontology
HyperlinkGene Summary
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq
Other Designations
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2|ATP sulfurylase/APS kinase 2|ATP sulfurylase/adenosine 5'-phosphosulfate kinase|PAPS synthase 2|PAPS synthetase 2|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2|phosphoadenosine-
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Interactome
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Pathway
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Disease
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Publication Reference
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Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization.
Xu ZH, Otterness DM, Freimuth RR, Carlini EJ, Wood TC, Mitchell S, Moon E, Kim UJ, Xu JP, Siciliano MJ, Weinshilboum RM.
Biochemical and Biophysical Research Communications 2000 Feb; 268(2):437.
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Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2.
Kurima K, Singh B, Schwartz NB.
The Journal of Biological Chemistry 1999 Nov; 274(47):33306.
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Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse.
Faiyaz ul Haque M, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH.
Nature Genetics 1998 Oct; 20(2):157.
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Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization.
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