NEK4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NEK4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human NEK4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with NEK4 polyclonal antibody (Cat # PAB3286) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — NEK4
Entrez GeneID
6787Protein Accession#
NEK4_HUMAN;NP_003148Gene Name
NEK4
Gene Alias
MGC33171, NRK2, STK2, pp12301
Gene Description
NIMA (never in mitosis gene a)-related kinase 4
Omim ID
601959Gene Ontology
HyperlinkOther Designations
serine/threonine kinase 2|serine/threonine protein kinase-2
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Interactome
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Disease
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Publication Reference
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The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.
Coene KL, Mans DA, Boldt K, Gloeckner CJ, van Reeuwijk J, Bolat E, Roosing S, Letteboer SJ, Peters TA, Cremers FP, Ueffing M, Roepman R.
Hum Mol Genet 2011 Jun; 20:3592.
Application:IF, WB-Ti, Bovine, Human, Rat, hTERT-RPE1 cells, Retinal, Renal tubule, Brain.
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The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.
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