Products

Western Blot (Tissue lysate)

Western blot analysis of mouse kidney tissue lysate (35 ug/lane) with TRPM7 polyclonal antibody (Cat # PAB3250).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with TRPM7 polyclonal antibody (Cat # PAB3250) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Entrez GeneID

54822

Protein Accession#

Q9BXB2

Gene Name

TRPM7

Gene Alias

CHAK, CHAK1, FLJ20117, FLJ25718, LTRPC7, TRP-PLIK

Gene Description

transient receptor potential cation channel, subfamily M, member 7

Omim ID

105500 605692

Gene Ontology

Hyperlink

Gene Summary

TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM

Other Designations

LTRPC ion channel family member 7