TRPM7 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with TRPM7 polyclonal antibody (Cat # PAB3249) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRPM7.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 1821-1850 of human TRPM7.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Saturated Ammonium Sulfate (SAS) precipitation
Recommend Usage
ELISA
Immunohistochemistry (1:50~100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide).
Storage Instruction
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with TRPM7 polyclonal antibody (Cat # PAB3249) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TRPM7
Entrez GeneID
54822Protein Accession#
Q96QT4; Q9BXB2Gene Name
TRPM7
Gene Alias
CHAK, CHAK1, FLJ20117, FLJ25718, LTRPC7, TRP-PLIK
Gene Description
transient receptor potential cation channel, subfamily M, member 7
Gene Ontology
HyperlinkGene Summary
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM
Other Designations
LTRPC ion channel family member 7
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Interactome
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Disease
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Publication Reference
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Oncogenic kinase signalling.
Blume-Jensen P, Hunter T.
Nature 2001 May; 411(6835):355.
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Phosphoinositide 3-kinase signalling pathways.
Cantrell DA.
Journal of Cell Science 2001 Apr; 114(Pt 8):1439.
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The RET proto-oncogene in human cancers.
Jhiang SM.
Oncogene 2000 Nov; 19(49):5590.
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Oncogenic kinase signalling.
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