PIP4K2B polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The PIP4K2B polyclonal antibody (Cat # PAB3236) is used in Western blot to detect PIP4K2B in NCI-H460 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with PIP4K2B polyclonal antibody (Cat # PAB3236) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PIP4K2B.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PIP4K2B.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The PIP4K2B polyclonal antibody (Cat # PAB3236) is used in Western blot to detect PIP4K2B in NCI-H460 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with PIP4K2B polyclonal antibody (Cat # PAB3236) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — PIP4K2B
Entrez GeneID
8396Protein Accession#
NP_003550Gene Name
PIP4K2B
Gene Alias
PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta
Gene Description
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Omim ID
603261Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq
Other Designations
1-phosphatidylinositol-4-phosphate kinase|PTDINS(4)P-5-kinase|diphosphoinositide kinase|phosphatidylinositol-4-phosphate 5-kinase, type II, beta
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Interactome
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Pathway
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Disease
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Publication Reference
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Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.
Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH.
Cell 1998 Sep; 94(6):829.
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A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase.
Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV.
The Journal of Biological Chemistry 1997 Feb; 272(9):5861.
Application：WB-Ce, Human, HeLa, MCF-7 cells.
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Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.
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