PIK3CD polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PIK3CD.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PIK3CD.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunofluorescence (1:10-50)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PIK3CD polyclonal antibody (Cat # PAB3215) in 293 cell line lysates. PIK3CD Antibody (N-term) (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinoma reacted with PIK3CD polyclonal antibody (Cat # PAB3215) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Immunofluorescence
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Gene Info — PIK3CD
Entrez GeneID
5293Protein Accession#
NP_005017;O00329Gene Name
PIK3CD
Gene Alias
p110D
Gene Description
phosphoinositide-3-kinase, catalytic, delta polypeptide
Omim ID
602839Gene Ontology
HyperlinkGene Summary
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.[supplied by OMIM
Other Designations
OTTHUMP00000001595|phosphatidylinositol 3-kinase, catalytic, delta polypeptide|phosphoinositide-3-kinase C
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Interactome
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Publication Reference
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Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.
Khan NA, Di Cello F, Nath A, Kim KS.
Journal of Neurovirology 2003 Dec; 9(6):584.
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Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement.
Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE.
Journal of Immunology 2003 Mar; 170(5):2647.
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HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.
Deregibus MC, Cantaluppi V, Doublier S, Brizzi MF, Deambrosis I, Albini A, Camussi G.
The Journal of Biological Chemistry 2002 May; 277(28):25195.
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Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.
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