HLA-A polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against recombinant human HLA Class I.
Immunogen
Recombinant protein corresponding to amino acids 115-308 of human HLA Class I.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Peptide affinity purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:50-1:200)
Immunohistochemistry
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)(1:200-1:500)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH7.4 (0.5% BSA, 50% Glycerol, 0.05% Sodium Azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of Hela cell lysate with HLA-A polyclonal antibody (Cat # PAB31856).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) staining of mouse stomach tissue with HLA-A polyclonal antibody (Cat # PAB31856).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) staining of human colon cancer with HLA-A polyclonal antibody (Cat # PAB31856).Flow Cytometry
Flow cytometry analysis of Jurkat cells with HLA-A polyclonal antibody (Cat # PAB31856). -
Gene Info — HLA-A
Entrez GeneID
3105Gene Name
HLA-A
Gene Alias
HLAA
Gene Description
major histocompatibility complex, class I, A
Gene Ontology
HyperlinkGene Summary
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq
Other Designations
HLA class I histocompatibility antigen, A-23 alpha chain|MHC class I antigen HLA-A heavy chain|MHC leukocyte antigen|OTTHUMP00000161059|antigen presenting molecule|leucocyte antigen class I|leukocyte antigen class I-A
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