STK39 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of STK39 polyclonal antibody (Cat # PAB3184) in mouse liver tissue lysate. STK39 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with STK39 polyclonal antibody (Cat # PAB3184) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STK39.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human STK39.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of STK39 polyclonal antibody (Cat # PAB3184) in mouse liver tissue lysate. STK39 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with STK39 polyclonal antibody (Cat # PAB3184) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — STK39
Entrez GeneID
27347Protein Accession#
NP_037365;Q9UEW8Gene Name
STK39
Gene Alias
DCHT, DKFZp686K05124, PASK, SPAK
Gene Description
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
Omim ID
607648Gene Ontology
HyperlinkGene Summary
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq
Other Designations
Ste20-like protein kinase|proline-alanine-rich STE20-related kinase|small intestine SPAK-like kinase
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Interactome
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Disease
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Publication Reference
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PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1).
Dowd BF, Forbush B.
The Journal of Biological Chemistry 2003 Jul; 278(30):27347.
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SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.
Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC, DeAizpurua HJ.
Oncogene 2000 Aug; 19(37):4290.
Application：WB-Ti, Mouse, Pancreas, Testis, Brain, Spleen, Lung, Kidney, Liver.
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PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1).
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