MAP3K14 polyclonal antibody
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More Files
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Western Blot
The MAP3K14 polyclonal antibody (Cat # PAB3183) is used in Western blot to detect MAP3K14 in 293 cell lysate (Lane 1) and rat testis tissue lysate (Lane 2) .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MAP3K14 polyclonal antibody (Cat # PAB3183) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAP3K14.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 126-155 at internal region of human MAP3K14.
Host
Rabbit
Reactivity
Human, Rat
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
The MAP3K14 polyclonal antibody (Cat # PAB3183) is used in Western blot to detect MAP3K14 in 293 cell lysate (Lane 1) and rat testis tissue lysate (Lane 2) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MAP3K14 polyclonal antibody (Cat # PAB3183) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — MAP3K14
Entrez GeneID
9020Protein Accession#
M3KE_HUMANGene Name
MAP3K14
Gene Alias
FTDCR1B, HS, HSNIK, NIK
Gene Description
mitogen-activated protein kinase kinase kinase 14
Omim ID
604655Gene Ontology
HyperlinkGene Summary
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq
Other Designations
serine/threonine protein-kinase
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Interactome
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Pathway
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Disease
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Publication Reference
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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K.
Nature 1999 Mar; 398(6724):252.
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The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.
Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ.
Human Genetics 1998 Sep; 103(3):345.
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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
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