Anti-Bevacizumab polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against Bevacizumab.
Target gene is VEGFA.Immunogen
Bevacizumab.
Host
Rabbit
Specificity
The product is specific for Bevacizumab. This antibody serves as an excellent positive control for Bevacizumab immunogenicity (ADA) assays.
Form
Lyophilized
Preparation Method
This antibody is produced from sera of a rabbit immunized with Bevacizumab.
Purification
Antigen affinity purification
Recommend Usage
ELISA (ELISA detection: 0.05-0.2 ug/mL) (Direct ELISA)
Immunogenicity assay
The optimal working dilution should be determined by the end user.Inhibitory IC50
N/A
Storage Buffer
Lyophilized from PBS, pH 7.4 (0.02% sodium azide).
Storage Instruction
Store at -20°C on dry atmosphere, lyophilized antibodies are stable at 1 years.
After reconstitution with deionized water (or equivalent) to a final concentration of 0.5 mg/mL, it can be stored for 2-3 weeks at 2-8°C or for up to 12 months at -20°C or below.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Anti-Bevacizumab polyclonal antibody (Cat # PAB31792) binds with Bevacizumab. Coating antigen: Bevacizumab, 1 ug/mL. Anti-Bevacizumab polyclonal antibody (Cat # PAB31792) dilution start from 1000 ng/mL. EC50 = 13.26 ng/mL.Immunogenicity assay
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Gene Info — VEGFA
Entrez GeneID
7422Gene Name
VEGFA
Gene Alias
MGC70609, VEGF, VEGF-A, VPF
Gene Description
vascular endothelial growth factor A
Gene Ontology
HyperlinkGene Summary
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq
Other Designations
vascular endothelial growth factor isoform VEGF165|vascular permeability factor
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Interactome
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