Anti-Tocilizumab polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against Tocilizumab.
Target gene is IL-6 receptor.Immunogen
Tocilizumab.
Host
Rabbit
Specificity
The product is specific for Tocilizumab. This antibody serves as an excellent positive control for Tocilizumab immunogenicity (ADA) assays.
Form
Lyophilized
Purification
Antigen affinity purification
Recommend Usage
ELISA (ELISA detection: 0.01-0.1 ug/mL) (Direct ELISA)
Immunogenicity assay
The optimal working dilution should be determined by the end user.Inhibitory IC50
N/A
Storage Buffer
Lyophilized from PBS, pH 7.4 (0.02% sodium azide).
Storage Instruction
Store at -20°C on dry atmospher. The lyophilized product remains stable up to 1 year at -20°C from date of receipt.
After reconstitution with deionized water (or equivalent) to a final concentration of 0.5 mg/mL, it can be stored for 2-3 weeks at 2-8°C or for up to 12 months at -20°C or below.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
ELISA binding of Anti-Tocilizumab polyclonal antibody (Cat # PAB31788) with Tocilizumab. Coating antigen: Tocilizumab, 1 ug/mL. Anti-Tocilizumab polyclonal antibody (Cat # PAB31788) dilution start from 1000 ng/mL. EC50 = 2.247 ng/mL.Immunogenicity assay
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Gene Info — IL6R
Entrez GeneID
3570Gene Name
IL6R
Gene Alias
CD126, IL-6R-1, IL-6R-alpha, IL6RA, MGC104991
Gene Description
interleukin 6 receptor
Omim ID
147880Gene Ontology
HyperlinkGene Summary
Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
CD126 antigen|OTTHUMP00000034320|interleukin 6 receptor alpha subunit
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