PRKAR2B (phospho S113) polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon cancer (left). Negative control was pre-absorbed by immunogen peptide (right).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of human PRKAR2B (phospho S113).
Immunogen
A synthetic peptide corresponding to amino acids 50-130 of human PRKAR2B (phospho S113).
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Specificity
This antibody detects endogenous levels of PKAII beta reg protein only when phosphorylated at S113.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
ELISA (1:10000)
Immunohistochemistry (1:100-300)
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 0.5% BSA and 0.02% sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon cancer (left). Negative control was pre-absorbed by immunogen peptide (right).Enzyme-linked Immunoabsorbent Assay
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Gene Info — PRKAR2B
Entrez GeneID
5577Protein Accession#
P31323Gene Name
PRKAR2B
Gene Alias
PRKAR2, RII-BETA
Gene Description
protein kinase, cAMP-dependent, regulatory, type II, beta
Omim ID
176912Gene Ontology
HyperlinkGene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq
Other Designations
H_RG363E19.2|WUGSC:H_RG363E19.2|cAMP-dependent protein kinase type II-beta regulatory chain|cAMP-dependent protein kinase, regulatory subunit beta 2
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Interactome
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Pathway
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