INPP5D (phospho Y1021) polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis of (1) KB cell lysate and (2) PC-3 cell lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of human INPP5D (phospho Y1021).
Immunogen
A synthetic peptide corresponding to amino acids 960-1040 of human INPP5D (phospho Y1021).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of INPP5D protein only when phosphorylated at Y1021.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
ELISA (1:40000)
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 0.5% BSA and 0.02% sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis of (1) KB cell lysate and (2) PC-3 cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — INPP5D
Entrez GeneID
3635Protein Accession#
Q92835Gene Name
INPP5D
Gene Alias
MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN
Gene Description
inositol polyphosphate-5-phosphatase, 145kDa
Omim ID
601582Gene Ontology
HyperlinkGene Summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
SH2 containing inositol phosphatase|SH2 containing inositol phosphatase, isoform b|p150Ship|signaling inositol polyphosphate 5 phosphatase SIP-145
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Interactome
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Pathway
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Disease
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