Products

Western Blot (Transfected lysate)

Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with GFRA2 polyclonal antibody (Cat # PAB31587).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lymph node with GFRA2 polyclonal antibody (Cat # PAB31587) shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra.

Entrez GeneID

2675

Protein Accession#

O00451

Gene Name

GFRA2

Gene Alias

GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2

Gene Description

GDNF family receptor alpha 2

Omim ID

601956

Gene Ontology

Hyperlink

Gene Summary

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

GFR-alpha 2|PI-linked cell-surface accessory protein|RET ligand 2|TGF-beta related neurotrophic factor receptor 2|TRN receptor, GPI-anchored|glial cell line derived neurotrophic factor receptor, beta|glial cell line-derived neurotrophic factor family rece