NFATC2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human NFATC2.
Immunogen
Recombinant protein corresponding to human NFATC2.
Sequence
GSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTN
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lymph node with NFATC2 polyclonal antibody (Cat # PAB31580) shows moderate cytoplasmic positivity in germinal center cells and non-germinal center cells. -
Gene Info — NFATC2
Entrez GeneID
4773Protein Accession#
Q13469Gene Name
NFATC2
Gene Alias
KIAA0611, NFAT1, NFATP
Gene Description
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Omim ID
600490Gene Ontology
HyperlinkGene Summary
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
NFAT pre-existing subunit|NFAT transcription complex, preexisting component|OTTHUMP00000031291|T cell transcription factor NFAT1|nuclear factor of activated T-cells, cytoplasmic 2|nuclear factor of activated T-cells, preexisting component|preexisting nucl
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Interactome
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Pathway
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Disease
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Publication Reference
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Epithelial calcineurin controls microbiota-dependent intestinal tumor development.
Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Röcken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S.
Nature Medicine 2016 May; 22(5):506.
Application:IF, IHC-P, Human, Mouse, Human colorectal cancer, Mouse small intestine.
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NFATc2 is an intrinsic regulator of melanoma dedifferentiation.
Perotti V, Baldassari P, Molla A, Vegetti C, Bersani I, Maurichi A, Santinami M, Anichini A, Mortarini R.
Oncogene 2016 Jun; 35(22):2862.
Application:IHC-P, Human, Human melanoma.
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Epithelial calcineurin controls microbiota-dependent intestinal tumor development.
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