ACACB polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western Blot analysis of human adipose tissue lysate with ACACB polyclonal antibody (Cat # PAB31507).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human soft tissue with ACACB polyclonal antibody (Cat # PAB31507) shows strong cytoplasmic and membranous positivity in adipocytes.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human ACACB.
Immunogen
Recombinant protein corresponding to human ACACB.
Sequence
ITKSKSEANLIPSQEPFPASDNSGETPQRNGEGHTLPKTPSQAEPASHKGPKDAGRRRNSLPPSHQKPPRNPLSSSDAAPSPELQANGTGTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:1000)
Western Blot (1:250-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of human adipose tissue lysate with ACACB polyclonal antibody (Cat # PAB31507).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human soft tissue with ACACB polyclonal antibody (Cat # PAB31507) shows strong cytoplasmic and membranous positivity in adipocytes. -
Gene Info — ACACB
Entrez GeneID
32Protein Accession#
O00763Gene Name
ACACB
Gene Alias
ACC2, ACCB, HACC275
Gene Description
acetyl-Coenzyme A carboxylase beta
Omim ID
601557Gene Ontology
HyperlinkGene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq
Other Designations
acetyl-CoA carboxylase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects.
Ma L, Murea M, Snipes JA, Marinelarena A, Krüger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA, Shores NJ, Rudel LL, Blüher M, Stumvoll M, Bowden DW, Maeda S, Parks JS, Kovacs P, Hanson RL, Baier LJ, Elbein SC, Freedman BI.
PLoS One 2013 Feb; 8(2):e56193.
Application：WB-Ti, Human, Liver.
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An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects.
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