GAD2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human GAD2.
Immunogen
Recombinant protein corresponding to human GAD2.
Sequence
SGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with GAD2 polyclonal antibody (Cat # PAB31500) shows cytoplasmic positivity in islets of Langerhans. -
Gene Info — GAD2
Entrez GeneID
2572Protein Accession#
Q05329Gene Name
GAD2
Gene Alias
GAD65, MGC161605, MGC161607
Gene Description
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Omim ID
138275Gene Ontology
HyperlinkGene Summary
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq
Other Designations
Glutamate decarboxylase-2 (pancreas)|OTTHUMP00000019335|OTTHUMP00000019336|glutamate decarboxylase 2|glutamate decarboxylase 2 (pancreatic islets and brain, 65kD)
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Interactome
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Pathway
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Disease
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