NLRP12 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human NLRP12.
Immunogen
Recombinant protein corresponding to human NLRP12.
Sequence
LKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human bone marrow with NLRP12 polyclonal antibody (Cat # PAB31495) shows cytoplasmic positivity in hematopoietic cells. -
Gene Info — NLRP12
Entrez GeneID
91662Protein Accession#
P59046Gene Name
NLRP12
Gene Alias
CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2
Gene Description
NLR family, pyrin domain containing 12
Omim ID
609648Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined. [provided by RefSeq
Other Designations
NACHT, LRR and PYD containing protein 12|NACHT, leucine rich repeat and PYD containing 12|OTTHUMP00000067226|PYRIN-containing APAF1-like protein 7|monarch 1|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12|regu
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Interactome
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Disease
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