PPM1B polyclonal antibody
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More Files
- More Functions
Western Blot
Western Blot analysis of (1) human cell line RT-4 (2) human cell line U-251MG sp (3) human plasma (IgG/HSA depleted) (4) human liver tissue, and (5) human tonsil tissue.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human duodenum shows cytoplasmic positivity in glandular cells.
Immunofluorescence
Immunofluorescent staining of human cell line A-431 shows positivity in nucleoli & cytoplasm. Antibody staining is shown in green.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human PPM1B.
Immunogen
Recombinant protein corresponding to amino acids 359-463 of human PPM1B.
Sequence
KRNVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRLAKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAEL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:50)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of (1) human cell line RT-4 (2) human cell line U-251MG sp (3) human plasma (IgG/HSA depleted) (4) human liver tissue, and (5) human tonsil tissue.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human duodenum shows cytoplasmic positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of human cell line A-431 shows positivity in nucleoli & cytoplasm. Antibody staining is shown in green. -
Gene Info — PPM1B
Entrez GeneID
5495Protein Accession#
O75688Gene Name
PPM1B
Gene Alias
MGC21657, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
Gene Description
protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform
Omim ID
603770Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq
Other Designations
OTTHUMP00000158953|OTTHUMP00000158955|protein phosphatase 1B|protein phosphatase 2C beta isoform|protein phosphatase 2C-like protein
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Interactome
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Pathway
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Disease
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