Products

Western Blot (Cell lysate)

Western blot analysis of CDH10 polyclonal antibody (Cat # PAB3147) in NCI-H460 cell line lysates (35 ug/lane). CDH10 (arrow) was detected using the purified polyclonal antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human brain tissue reacted with CDH10 polyclonal antibody (Cat # PAB3147) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Flow Cytometry

Flow cytometric analysis of NCI-H460 cells using CDH10 polyclonal antibody (Cat # PAB3147)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Entrez GeneID

1008

Protein Accession#

NP_006718;Q9Y6N8

Gene Name

CDH10

Gene Alias

-

Gene Description

cadherin 10, type 2 (T2-cadherin)

Omim ID

604555

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. [provided by RefSeq

Other Designations

T2-cadherin|cadherin 10, type 2|cadherin-10