Products

Western Blot (Transfected lysate)

Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with PDE6A polyclonal antibody (Cat # PAB31469).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skeletal muscle with PDE6A polyclonal antibody (Cat # PAB31469) shows strong cytoplasmic positivity in myocytes.

Entrez GeneID

5145

Protein Accession#

P16499

Gene Name

PDE6A

Gene Alias

CGPR-A, PDEA

Gene Description

phosphodiesterase 6A, cGMP-specific, rod, alpha

Omim ID

180071

Gene Ontology

Hyperlink

Gene Summary

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq

Other Designations

cGMP phosphodiesterase alpha subunit|phosphodiesterase 6A, alpha subunit|rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha|rod photoreceptor cGMP phosphodiesterase alpha subunit