GPR77 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with GPR77 polyclonal antibody (Cat # PAB31464).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human small intestine with GPR77 polyclonal antibody (Cat # PAB31464) shows distinct positivity in subset of glandular cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human GPR77.
Immunogen
Recombinant protein corresponding to human GPR77.
Sequence
NDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLR
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:50)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with GPR77 polyclonal antibody (Cat # PAB31464).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human small intestine with GPR77 polyclonal antibody (Cat # PAB31464) shows distinct positivity in subset of glandular cells. -
Gene Info — GPR77
Entrez GeneID
27202Protein Accession#
Q9P296Gene Name
GPR77
Gene Alias
C5L2, GPF77
Gene Description
G protein-coupled receptor 77
Omim ID
609949Gene Ontology
HyperlinkGene Summary
The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).[supplied by OMIM
Other Designations
G protein-coupled receptor C5L2
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Interactome
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Pathway
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