Products

Western Blot (Transfected lysate)

Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with SIGLEC5 polyclonal antibody (Cat # PAB31413).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human bone marrow with SIGLEC5 polyclonal antibody (Cat # PAB31413) shows strong cytoplasmic positivity in subsets of bone marrow poietic cells.

Entrez GeneID

8778

Protein Accession#

O15389

Gene Name

SIGLEC5

Gene Alias

CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5

Gene Description

sialic acid binding Ig-like lectin 5

Omim ID

604200

Gene Ontology

Hyperlink

Gene Summary

The sialic acid-binding immunoglobulin-like lectins (SIGLECs), such as SIGLEC5, are a subgroup of the immunoglobulin (Ig) superfamily that mediate protein-carbohydrate interactions. They specifically interact with sialic acids in glycoproteins and glycolipids, with each SIGLEC having a particular preference for both the nature of the sialic acid and its glycosidic linkage to adjacent sugars. SIGLECs have similar structures, including extracellular Ig-like domains composed of an N-terminal V-set domain followed by varying numbers of C2-set domains. It appears that all SIGLECs have an unusual arrangement of conserved cysteine residues in the V-set and adjacent C2-set domains. Most SIGLECs are expressed uniquely within the hematopoietic system (Cornish et al., 1998 [PubMed 9731071]).[supplied by OMIM

Other Designations

CD33 antigen-like 2|OB binding protein-2|sialic acid-binding immunoglobulin-like lectin 5