SSTR2 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with SSTR2 polyclonal antibody (Cat # PAB31385).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebral cortex with SSTR2 polyclonal antibody (Cat # PAB31385) shows strong positivity in neuropil, neuronal cells were weakly stained.
Immunofluorescence
Immunofluorescent staining of A-431 cells with SSTR2 polyclonal antibody (Cat # PAB31385) (Green) shows localization to cytosol.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human SSTR2.
Immunogen
Recombinant protein corresponding to human SSTR2.
Sequence
DNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:50)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with SSTR2 polyclonal antibody (Cat # PAB31385).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebral cortex with SSTR2 polyclonal antibody (Cat # PAB31385) shows strong positivity in neuropil, neuronal cells were weakly stained.Immunofluorescence
Immunofluorescent staining of A-431 cells with SSTR2 polyclonal antibody (Cat # PAB31385) (Green) shows localization to cytosol. -
Gene Info — SSTR2
Entrez GeneID
6752Protein Accession#
P30874Gene Name
SSTR2
Gene Alias
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Gene Description
somatostatin receptor 2
Omim ID
182452Gene Ontology
HyperlinkGene Summary
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Loss of somatostatin receptor subtype 2 in prostate cancer is linked to an aggressive cancer phenotype, high tumor cell proliferation and predicts early metastatic and biochemical relapse.
Hennigs JK, Müller J, Adam M, Spin JM, Riedel E, Graefen M, Bokemeyer C, Sauter G, Huland H, Schlomm T, Minner S.
PLoS One 2014 Jul; 9(7):e100469.
Application：IHC-P, Human, Human prostate cancer, Human tissue microarray.
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Binding of TS1, an anti-keratin 8 antibody, in small-cell lung cancer after 177Lu-DOTA-Tyr3-octreotate treatment: a histological study in xenografted mice.
Erlandsson A, Forssell-Aronsson E, Seidal T, Bernhardt P.
EJNMMI Research 2011 Aug; 1(1):19.
Application：IHC-P, Human, Mouse, Human small-cell lung carcinoma-xenografted mice.
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ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy.
Minner S, Enodien M, Sirma H, Luebke AM, Krohn A, Mayer PS, Simon R, Tennstedt P, Müller J, Scholz L, Brase JC, Liu AY, Schlüter H, Pantel K, Schumacher U, Bokemeyer C, Steuber T, Graefen M, Sauter G, Schlomm T.
Clinical Cancer Research 2011 Sep; 17(18):5878.
Application：IHC-P, Human, Human prostate cancer, Human tissue microarray.
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Loss of somatostatin receptor subtype 2 in prostate cancer is linked to an aggressive cancer phenotype, high tumor cell proliferation and predicts early metastatic and biochemical relapse.
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