CDH12 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CDH12 polyclonal antibody (Cat # PAB3136) in Jurkat cell line lysates (35 ug/lane). CDH12 (arrow) was detected using the purified polyclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human brain tissue reacted with CDH12 polyclonal antibody (Cat # PAB3136) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDH12.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CDH12.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CDH12 polyclonal antibody (Cat # PAB3136) in Jurkat cell line lysates (35 ug/lane). CDH12 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human brain tissue reacted with CDH12 polyclonal antibody (Cat # PAB3136) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — CDH12
Entrez GeneID
1010Protein Accession#
NP_004052;P55289Gene Name
CDH12
Gene Alias
CDHB, FLJ34857
Gene Description
cadherin 12, type 2 (N-cadherin 2)
Omim ID
600562Gene Ontology
HyperlinkGene Summary
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq
Other Designations
Br-cadherin|N-cadherin 2|OTTHUMP00000115709|brain-cadherin|cadherin 12, type 2|cadherin, neural type, 2|cadherin-12|neuronal cadherin 2
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Interactome
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Disease
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Publication Reference
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Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M.
The Biochemical Journal 2000 Jul; 349(Pt 1):159.
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Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma.
Chalmers IJ, Hofler H, Atkinson MJ.
Genomics 1999 Apr; 57(1):160.
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Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.
Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF.
Genomics 1998 May; 49(3):467.
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Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.
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