HPGD polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human HPGD.
Immunogen
Recombinant protein corresponding to human HPGD.
Sequence
VDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPV
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of HEL cell lysate with HPGD polyclonal antibody (Cat # PAB31351).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human stomach with HPGD polyclonal antibody (Cat # PAB31351) shows strong cytoplasmic and membranous positivity in glandular cells. -
Gene Info — HPGD
Entrez GeneID
3248Protein Accession#
P15428Gene Name
HPGD
Gene Alias
15-PGDH, PGDH, PGDH1, SDR36C1
Gene Description
hydroxyprostaglandin dehydrogenase 15-(NAD)
Omim ID
601688Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
15-hydroxy prostaglandin dehydrogenase|15-hydroxyprostaglandin dehydrogenase|NAD+-dependent 15-hydroxyprostaglandin dehydrogenase|short chain dehydrogenase/reductase family 36C, member 1
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Interactome
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Disease
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Publication Reference
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Characterization of transcriptional changes in ERG rearrangement-positive prostate cancer identifies the regulation of metabolic sensors such as neuropeptide Y.
Massoner P, Kugler KG, Unterberger K, Kuner R, Mueller LA, Fälth M, Schäfer G, Seifarth C, Ecker S, Verdorfer I, Graber A, Sültmann H, Klocker H.
PLoS One 2013 Feb; 8(2):e55207.
Application:IHC-P, Human, Human prostate cancer, Human tissue microarray.
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Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas.
Wu CC, Hsu CW, Chen CD, Yu CJ, Chang KP, Tai DI, Liu HP, Su WH, Chang YS, Yu JS.
Molecular & Cellular Proteomics 2010 Jun; 9(6):1100.
Application:IHC, Human, Colon, Liver, Bladder, Breast, Lung cancer.
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Characterization of transcriptional changes in ERG rearrangement-positive prostate cancer identifies the regulation of metabolic sensors such as neuropeptide Y.
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