ALDH6A1 polyclonal antibody
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More Files
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Western Blot (Transfected lysate)
Western blot analysis of ALDH6A1 (arrow) using rabbit ALDH6A1 polyclonal antibody (Cat # PAB3128). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ALDH6A1 gene (Lane 2) (Origene Technologies).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with ALDH6A1 polyclonal antibody (Cat # PAB3128) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ALDH6A1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ALDH6A1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of ALDH6A1 (arrow) using rabbit ALDH6A1 polyclonal antibody (Cat # PAB3128). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ALDH6A1 gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with ALDH6A1 polyclonal antibody (Cat # PAB3128) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — ALDH6A1
Entrez GeneID
4329Protein Accession#
NP_005580;Q02252Gene Name
ALDH6A1
Gene Alias
MGC40271, MMSADHA, MMSDH
Gene Description
aldehyde dehydrogenase 6 family, member A1
Omim ID
603178Gene Ontology
HyperlinkGene Summary
This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. [provided by RefSeq
Other Designations
aldehyde dehydrogenase 6A1|mitochondrial acylating methylmalonate-semialdehyde dehydrogenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Assignment of the PAX6 gene to bovine chromosome 15q25-->q27 by fluorescence in situ hybridization and confirmation by radiation hybrid mapping.
Kuiper H, Williams JL, Distl O, Drogemuller C.
Cytogenetic and Genome Research 2005 Sep; 109(4):533.
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The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A.
Molecular & Cellular Proteomics 2004 Apr; 3(4):311.
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Molecular characterization of methylmalonate semialdehyde dehydrogenase deficiency.
Chambliss KL, Gray RG, Rylance G, Pollitt RJ, Gibson KM.
Journal of Inherited Metabolic Disease 2000 Jul; 23(5):497.
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Assignment of the PAX6 gene to bovine chromosome 15q25-->q27 by fluorescence in situ hybridization and confirmation by radiation hybrid mapping.
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