MYOT polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skeletal muscle with MYOT polyclonal antibody (Cat # PAB31205) shows strong cytoplasmic positivity in myocytes.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human MYOT.
Immunogen
Recombinant protein corresponding to human MYOT.
Sequence
MSSSAFPASPQQHAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPDHEIQG
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skeletal muscle with MYOT polyclonal antibody (Cat # PAB31205) shows strong cytoplasmic positivity in myocytes. -
Gene Info — MYOT
Entrez GeneID
9499Protein Accession#
Q9UBF9Gene Name
MYOT
Gene Alias
LGMD1, LGMD1A, TTID
Gene Description
myotilin
Gene Ontology
HyperlinkGene Summary
This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined
Other Designations
titin immunoglobulin domain protein (myotilin)
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Interactome
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Disease
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