Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human prostate with SEPP1 polyclonal antibody (Cat # PAB31199) shows strong cytoplasmic positivity in glandular cells.

Immunofluorescence

Immunofluorescent staining of HepG2 with SEPP1 polyclonal antibody (Cat # PAB31199) (Green) shows localization to nucleus and the Golgi apparatus.

Entrez GeneID

6414

Protein Accession#

P49908

Gene Name

SEPP1

Gene Alias

SELP, SeP

Gene Description

selenoprotein P, plasma, 1

Omim ID

601484

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene. [provided by RefSeq

Other Designations

selenoprotein P