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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human small intestine with EPHA8 polyclonal antibody (Cat # PAB31169) shows strong membranous positivity in glandular cells.

Entrez GeneID

2046

Protein Accession#

P29322

Gene Name

EPHA8

Gene Alias

EEK, HEK3, KIAA1459

Gene Description

EPH receptor A8

Omim ID

176945

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq

Other Designations

EPH- and ELK-related tyrosine kinase|OTTHUMP00000002934|OTTHUMP00000002935|ephrin type-A receptor 8|hydroxyaryl-protein kinase|protein-tyrosine kinase|tyrosine-protein kinase receptor EEK|tyrosylprotein kinase