FLG polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against partial recombinant human FLG.
Immunogen
Recombinant protein corresponding to human FLG.
Sequence
SADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESAR
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:2500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human vulva/anal skin with FLG polyclonal antibody (Cat # PAB31145) shows strong cytoplasmic positivity in superficial layer of squamous epithelium. -
Gene Info — FLG
Entrez GeneID
2312Protein Accession#
P20930Gene Name
FLG
Gene Alias
ATOD2
Gene Description
filaggrin
Gene Ontology
HyperlinkGene Summary
Profilaggrin is a major protein component of the keratohyalin granules of mammalian epidermis. It is initially expressed as a large polyprotein precursor which is subsequently proteolytically processed into individual functional filaggrin molecules. The filaggrins show wide species variations and their aberrant expression has been implicated in a number of keratinizing disorders (Baden et al., 1974 [PubMed 4132224]; Holbrook et al., 1982 [PubMed 6174530]; Sybert et al., 1985 [PubMed 2579164]).[supplied by OMIM
Other Designations
OTTHUMP00000014057|epidermal filaggrin
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Interactomes
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Diseases
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