PTPRA polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cardiac muscle with PTPRA polyclonal antibody (Cat # PAB31129) shows strong cytoplasmic positivity in myocytes.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human PTPRA.
Immunogen
Recombinant protein corresponding to human PTPRA.
Sequence
IWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGM
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cardiac muscle with PTPRA polyclonal antibody (Cat # PAB31129) shows strong cytoplasmic positivity in myocytes. -
Gene Info — PTPRA
Entrez GeneID
5786Protein Accession#
P18433Gene Name
PTPRA
Gene Alias
HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA
Gene Description
protein tyrosine phosphatase, receptor type, A
Omim ID
176884Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq
Other Designations
Leukocyte common antigen-related peptide (protein tyrosine phosphate)|OTTHUMP00000030063|OTTHUMP00000030064|OTTHUMP00000030065|PTPLCA-related phosphatase|PTPase-alpha|protein tyrosine phosphatase, receptor type, alpha polypeptide|tyrosine phosphatase alph
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Interactome
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Disease
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Publication Reference
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Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction.
Carotenuto M, Pedone E, Diana D, de Antonellis P, Dzeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M.
Scientific Reports 2013 Jan; 3:1351.
Application：IHC-P, WB-Ce, Human, Mouse, Mouse xenograft-tumors of SH-SY5Y cells, SH-SY5Y cells.
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Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction.
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