HMGCL polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human HMGCL.
Immunogen
Recombinant protein corresponding to amino acids 43-184 of human HMGCL.
Sequence
GLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAK
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of human cell line RT-4.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human liver shows strong cytoplasmic positivity in hepatocytes. -
Gene Info — HMGCL
Entrez GeneID
3155Protein Accession#
P35914Gene Name
HMGCL
Gene Alias
HL
Gene Description
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
Omim ID
246450Gene Ontology
HyperlinkOther Designations
3-hydroxy-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)|3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)|OTTHUMP00000044830|hydroxymethylglutaricaciduria
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Interactome
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Pathway
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Disease
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Publication Reference
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Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.
Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D, Howell A, Lisanti MP, Sotgia F.
Cell Cycle 2012 Nov; 11(21):3956.
Application:IF, IHC-P, Human, Human breast cancers, MCF-7 cells.
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Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.
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