GRB2 polyclonal antibody
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More Files
- More Functions
Western Blot
Western Blot analysis of (1) Human RT-4 cell, (2) Human U-251MG cell, (3) Human plasma, (4) Human liver tissue, (5) Human tonsil tissue.
Immunofluorescence
Immunofluorescent staining of PC-3 cell line with antibody shows positivity in nucleus and nucleoli (green).
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human GRB2.
Immunogen
Recombinant protein corresponding to human GRB2.
Sequence
KVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPT
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:100-250)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of (1) Human RT-4 cell, (2) Human U-251MG cell, (3) Human plasma, (4) Human liver tissue, (5) Human tonsil tissue.Immunofluorescence
Immunofluorescent staining of PC-3 cell line with antibody shows positivity in nucleus and nucleoli (green). -
Gene Info — GRB2
Entrez GeneID
2885Protein Accession#
P62993Gene Name
GRB2
Gene Alias
ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084
Gene Description
growth factor receptor-bound protein 2
Omim ID
108355Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
HT027|OTTHUMP00000166096|OTTHUMP00000166097|OTTHUMP00000166098|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3
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Interactome
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Pathway
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Disease
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