BRCA2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human BRCA2.
Immunogen
Recombinant protein corresponding to human BRCA2.
Sequence
VHPISLSSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENEDNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQIKEDLS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescent staining of U-251MG cell line with antibody shows positivity in nucleoplasm and cytosol (green). -
Gene Info — BRCA2
Entrez GeneID
675Protein Accession#
P51587Gene Name
BRCA2
Gene Alias
BRCC2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1
Gene Description
breast cancer 2, early onset
Gene Ontology
HyperlinkGene Summary
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq
Other Designations
BRCA1/BRCA2-containing complex, subunit 2|OTTHUMP00000018803|OTTHUMP00000042401|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer susceptibility protein BRCA2
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Interactome
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Pathway
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Disease
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Publication Reference
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53BP1 fosters fidelity of homology-directed DNA repair.
Fena Ochs, Kumar Somyajit, Matthias Altmeyer, Maj-Britt Rask, Jiri Lukas, Claudia Lukas.
Nature Structural & Molecular Biology 2016 Aug; 23(8):714.
Application:WB-Ce, Human, U-2 OS cells.
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53BP1 fosters fidelity of homology-directed DNA repair.
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