CREBBP polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon shows strong nuclear positivity in glandular cells.
Immunofluorescence
Immunofluorescent staining of MCF7 cell line with antibody shows positivity in nucleoplasm and nuclear bodies (green).
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human CREBBP.
Immunogen
Recombinant protein corresponding to human CREBBP.
Sequence
VASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDE
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-200)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon shows strong nuclear positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of MCF7 cell line with antibody shows positivity in nucleoplasm and nuclear bodies (green). -
Gene Info — CREBBP
Entrez GeneID
1387Protein Accession#
Q92793Gene Name
CREBBP
Gene Alias
CBP, KAT3A, RSTS
Gene Description
CREB binding protein
Gene Ontology
HyperlinkGene Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
Rubinstein-Taybi syndrome
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Interactome
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Pathway
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Disease
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