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Last updated: 2017/7/23

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MLH1 polyclonal antibody

  • Catalog # : PAB31059
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against partial recombiant human MLH1.
  • Immunogen:
  • Recombinant protein corresponding to human MLH1.
  • Sequence:
  • TKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSE
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-50)
    Immunofluorescence (1-4 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of human tonsil shows moderate nuclear positivity in germinal center cells.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of U-251MG cell line with antibody shows positivity in nucleoplasma (green).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4292
  • Gene Name:
  • MLH1
  • Gene Alias:
  • COCA2,FCC2,HNPCC,HNPCC2,MGC5172,hMLH1
  • Gene Description:
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
  • Gene Summary:
  • This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. [provided by RefSeq
  • Other Designations:
  • DNA mismatch repair protein Mlh1,MutL protein homolog 1
  • Related Disease
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