ITGA5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: mouse NIH-3T3, Lane 2: rat NBT-II and Lane 3: rat PC12 cell lysates with ITGA5 polyclonal antibody (Cat # PAB31001).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta with ITGA5 polyclonal antibody (Cat # PAB31001) shows strong membranous positivity in trophoblastic cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human ITGA5.
Immunogen
Recombinant protein corresponding to human ITGA5.
Sequence
DQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRSSASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWA
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2500)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: mouse NIH-3T3, Lane 2: rat NBT-II and Lane 3: rat PC12 cell lysates with ITGA5 polyclonal antibody (Cat # PAB31001).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta with ITGA5 polyclonal antibody (Cat # PAB31001) shows strong membranous positivity in trophoblastic cells. -
Gene Info — ITGA5
Entrez GeneID
3678Protein Accession#
P08648Gene Name
ITGA5
Gene Alias
CD49e, FNRA, VLA5A
Gene Description
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Omim ID
135620Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
Other Designations
fibronectin receptor, alpha subunit|integrin alpha 5|very late activation protein 5, alpha subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Survivin promotion of melanoma metastasis requires upregulation of α5 integrin.
McKenzie JA, Liu T, Jung JY, Jones BB, Ekiz HA, Welm AL, Grossman D.
Carcinogenesis 2013 Sep; 34(9):2137.
Application：IHC-P, WB-Tr, Human, YUSAC2 cells.
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Survivin promotion of melanoma metastasis requires upregulation of α5 integrin.
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