INSL3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human INSL3.
Immunogen
Recombinant protein corresponding to human INSL3.
Sequence
EMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDRELLQWLERRHLLHGLVADSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with INSL3 polyclonal antibody (Cat # PAB30995) shows strong cytoplasmic positivity in Leydig cells. -
Gene Info — INSL3
Entrez GeneID
3640Protein Accession#
P51460Gene Name
INSL3
Gene Alias
MGC119818, MGC119819, RLF, RLNL
Gene Description
insulin-like 3 (Leydig cell)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism. [provided by RefSeq
Other Designations
insulin-like 3|leydig insulin -like hormone|leydig insulin -like peptide|relaxin-like factor b
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Interactome
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Disease
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Publication Reference
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Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells.
Marie Berg Nygaard, Kristian Almstrup, Louise Lindbæk, Søren Tvorup Christensen, Terje Svingen.
Scientific Reports 2015 May; 5:10364.
Application:IF, IHC-P, Human, Human testes.
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The human testis-specific proteome defined by transcriptomics and antibody-based profiling.
Djureinovic D, Fagerberg L, Hallstrom B, Danielsson A, Lindskog C, Uhlen M, Ponten F.
Molecular Human Reproduction 2014 Jun; 20(6):476.
Application:IHC, Human, Human testes.
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Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells.
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