Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with CEP350 polyclonal antibody (Cat # PAB30989) shows strong cytoplasmic positivity in cells of seminiferous ducts and Leydig cells.
The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq
OTTHUMP00000060646,centrosome associated protein 350,centrosome-associated protein 350