EPB49 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human EPB49.
Immunogen
Recombinant protein corresponding to human EPB49.
Sequence
SKSSSLPAYGRTTLSRLQSTEFSPSGSETGSPGLQNGEGQRGRMDRGNSLPCVLEQKIYPYEMLVVTNKGRTKLPP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with EPB49 polyclonal antibody (Cat # PAB30945) shows strong cytoplasmic positivity in subsets of cells. -
Gene Info — EPB49
Entrez GeneID
2039Protein Accession#
Q08495Gene Name
EPB49
Gene Alias
DMT, FLJ78462, FLJ98848
Gene Description
erythrocyte membrane protein band 4.9 (dematin)
Omim ID
125305Gene Ontology
HyperlinkGene Summary
Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after dephosphorylation (Rana et al., 1993 [PubMed 8341682]).[supplied by OMIM
Other Designations
dematin|erythrocyte membrane protein band 4.9
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Interactome
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Publication Reference
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Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells.
Charlotte Stadler, Elton Rexhepaj, Vasanth R Singan, Robert F Murphy, Rainer Pepperkok, Mathias Uhlén, Jeremy C Simpson, Emma Lundberg.
Nature Methods 2013 Apr; 10(4):315.
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Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells.
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