Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Entrez GeneID

Protein Accession#

Gene Name

MMP16

Gene Alias

C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP

Gene Description

matrix metallopeptidase 16 (membrane-inserted)

Omim ID

Gene Ontology

Gene Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq

Other Designations

matrix metalloproteinase 16|matrix metalloproteinase 16 (membrane-inserted)|membrane-type matrix metalloproteinase 3|membrane-type-3 matrix metalloproteinase