DLL4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human DLL4.
Immunogen
Recombinant protein corresponding to human DLL4.
Sequence
CHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with DLL4 polyclonal antibody (Cat # PAB30936) shows strong luminal membrane positivity in tubular cells -
Gene Info — DLL4
Entrez GeneID
54567Protein Accession#
Q9NR61Gene Name
DLL4
Gene Alias
MGC126344, hdelta2
Gene Description
delta-like 4 (Drosophila)
Omim ID
605185Gene Ontology
HyperlinkGene Summary
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq
Other Designations
delta 4|delta ligand 4|delta-like 4 homolog|delta-like 4 protein|notch ligand DLL4|notch ligand delta-2
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Pathway
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Publication Reference
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Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation.
Vo K, Amarasinghe B, Washington K, Gonzalez A, Berlin J, Dang TP.
Molecular Cancer 2011 Nov; 10:138.
Application:IHC-P, Human, Human pancreatic cancer, Human tissue microarray.
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Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation.
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