SLIT2 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against partial recombinant human SLIT2.
Immunogen
Recombinant protein corresponding to human SLIT2.
Sequence
LYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLE
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human stomach with SLIT2 polyclonal antibody (Cat # PAB30933) shows strong cytoplasmic and membranous positivity in glandular cells. -
Gene Info — SLIT2
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation.
Beggs AD, Jones A, Shepherd N, Arnaout A, Finlayson C, Abulafi AM, Morton DG, Matthews GM, Hodgson SV, Tomlinson IP.
PLoS Pathogens 2013 May; 9(5):e1003488.
Application:IHC-P, Human, Colonic adenoma, Normal colonic mucosa, Serrated adenoma tissues.
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Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium.
Brantley-Sieders DM, Dunaway CM, Rao M, Short S, Hwang Y, Gao Y, Li D, Jiang A, Shyr Y, Wu JY, Chen J.
Cancer Research 2011 Feb; 71(3):976.
Application:IHC, Human, Breast cancer.
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The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.
Yu J, Cao Q, Yu J, Wu L, Dallol A, Li J, Chen G, Grasso C, Cao X, Lonigro RJ, Varambally S, Mehra R, Palanisamy N, Wu JY, Latif F, Chinnaiyan AM.
Oncogene 2010 Sep; 29(39):5370.
Application:IHC-P, WB-Tr, Human, H16N2 cells, HEK 293 cells, Human prostate cancer, Human tissue microarray, LNCaP cells, RWPE cells.
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Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation.
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